News-Medical.Net December 12, 2025
Mass General Brigham is announcing the spinout of AIwithCare, a company founded by researchers from the health system who developed an artificial intelligence (AI) screening tool that significantly outperformed manual screening for determining a patient’s eligibility and enrolling them in a clinical trial.
The tool, RECTIFIER (RAG-Enabled Clinical Trial Infrastructure for Inclusion Exclusion Review), was first developed and studied by researchers at Mass General Brigham’s Accelerator for Clinical Transformation. Since the publications of a proof-of-concept study in June 2024 and prospective, randomized-controlled, blinded trial in February 2025, RECTIFIER’s use has continued to expand across the healthcare system, with more than 20 active and onboarding use cases in research and clinical operations, including in cardiology, oncology, gastroenterology, neurology, pathology and psychiatry.
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