Major depressive disorder study finds differences between male and female brain processes at molecular level

Medical Xpress October 16, 2023
Jane Davis, University of Wollongong

Research published in Neuropsychopharmacology by a team of researchers at the University of Wollongong (UOW), National Institute of Complementary Medicine Health Research Institute and Neuroscience Research Australia has found molecular evidence highlighting important sex differences in the brains of people with major depressive disorder, with evidence of changes occurring specifically in the female brain, but not in males. The paper is titled “Sex- and suicide-specific alterations in the kynurenine pathway in the anterior cingulate cortex in major depression.”

“We can no longer just look at depression with males and females together because, even at a fundamental level, the brains are so different biologically that when we group them all together for these studies, we miss so much,” the study’s lead...

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