Medical Xpress November 26, 2024
Gladstone Institutes

Subtle signs of Alzheimer’s disease can emerge decades before a diagnosis—often in the form of irregular behaviors that reflect very early stages of brain dysfunction. But until now, identifying and measuring these slight behavioral changes in a scientific way hasn’t been feasible, not even when studying Alzheimer’s in mice.

In a study published in Cell Reports, a team of scientists at Gladstone Institutes used a new video-based tool to pinpoint otherwise-undetectable signs of early disease in that were engineered to mimic key aspects of Alzheimer’s. Their work sheds light on a new strategy for identifying neurological disease earlier than currently possible and tracking how it develops over time.

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