LSD for anxiety treatment: 6 things to know

Becker's Healthcare September 5, 2025
Ella Ruder

A single dose of MM120, an oral pharmaceutical formulation of LSD, significantly reduced symptoms of generalized anxiety disorder in a randomized, placebo-controlled trial published Sept. 4 in JAMA Psychiatry.

Here are six things to know:

1. The clinical trial enrolled 198 adults aged 18 to 74 with moderate to severe generalized anxiety disorder diagnoses across 22 U.S. outpatient psychiatric sites. Participants were randomized to receive a single dose of MM120 of 25, 50, 100 or 200 micrograms or a placebo.

2. The study found a statistically significant dose-response relationship when assessing anxiety reduction at week four, as measured by the Hamilton Anxiety Rating Scale.

3. Specifically, the two higher doses of 100 or 200 micrograms led to a...

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