NEJM December 9, 2024
Winnie Byanyima, M.Sc., Linda-Gail Bekker, M.B., Ch.B., Ph.D. and Matthew M. Kavanagh, Ph.D.

The world may look back on 2024 as a pivotal time in the fight against AIDS — the start of a revolution in the global biomedical response to HIV using long-acting antiretroviral medicines. Young women in southern Africa have described new prevention options as empowering, allowing them to “own their own sexual destiny” for the first time. Young people with HIV, many of whom have lived their lives dependent on daily pills, long to be free of the daily reminder of their stigmatizing infection. Members of criminalized groups, such as gay men in Uganda and Malaysia, are seeking HIV options they can leave at the clinic. New long-acting prevention and treatment innovations have the potential to change the HIV narrative...

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