Medical Xpress January 21, 2026
Public Library of Science

A new medical large language model (LLM) achieved over 91% accuracy in identifying female participants diagnosed with major depressive disorder after analyzing a short WhatsApp audio recording where participants described their week, according to a study published in PLOS Mental Health by Victor H. O. Otani, from Santa Casa de São Paulo School of Medical Sciences and Infinity Doctors Inc., Brazil, and colleagues.

Study design and participant details

Major depressive disorder is a mental health condition that affects over 280 million people globally, and early detection can be critical for timely treatment. Here, Otani and colleagues used machine learning models to classify individuals with and without major depressive disorder based on WhatsApp voice messages.

The authors used two datasets for...

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