Eric Topol November 24, 2024
A Hyper-Accelerated Phase of New Foundation Models
Antedating the world’s notice of large language models (aka generative A.I.) with ChatGPT in November 2022 was AlphaFold2, published in the previous year. I wrote about it extensively in a prior GT edition. A quick summary: it was the 2021 Science Breakthrough of the Year, solving the >50-year protein folding problem. With the capability of predicting 3-D structure for >200 million proteins from amino acid sequence, made open-source, now having been used by more than 2 million researchers in 190 countries, AlphaFold2 quickly transformed life science research. It was also recognized by the 2024 Nobel Prize in Chemistry to Demis Hassabis and John Jumper, along with David Baker for A.I. protein design work.This...
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