Inside Precision Medicine May 15, 2024
Alice McCarthy

Researchers from the Vanderbilt-Ingram Cancer Center identified new genome-wide gene variants at 12 different locations associated with breast cancer in women of African ancestry. They discovered that variants in three of the 12 were associated with triple-negative breast cancer (TNBC).

Historically, women of African ancestry have been largely underrepresented in studies of germline susceptibility to cancer. This study, published in Nature Genetics, is the largest GWAS for breast cancer in this population. The team analyzed the genome of 18,034 women of African ancestry with breast cancer and 22,104 controls. Slightly more than 85 percent of the women in the study were from the U.S. with 14.7 percent from the African continent and Barbados.

Of the 12 loci that reached the...

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