Medscape March 24, 2025
A recent analysis of the US Food and Drug Administration Adverse Event Reporting System (FAERS) data found that beyond the reported associated risks for depression and suicidality, patients taking isotretinoin also can experience significant mood disturbances, self-injury, and psychoses. The authors therefore advised closely monitoring for such events in patients, especially during early treatment for acne.
However, an acne expert predicted that the study, recently published in the Journal of the American Academy of Dermatology, will have little clinical impact because of methodological issues.
With conflicting evidence and controversy surrounding the association of isotretinoin with psychiatric adverse events (AEs), wrote the authors led by Wenjia Nie, MD, of the Dermatology Hospital of Jiangxi Province in Jiangxi, China, it remains unclear...
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