Andreessen Horowitz April 12, 2023
By Vineeta Agarwala

“The power in tailored therapeutics is for us to say more clearly to payers, providers, and patients: ‘this drug is not for everyone, but it is for you.’ That is exceedingly powerful.” —John C. Lechleiter, Ph.D., former Chairman, President, and CEO, Eli Lilly and Company, in comments published by The Personalized Medicine Coalition (PMC)

The precision medicine paradigm is a powerful one–for cancer patients, and for the entire oncology ecosystem. Over 50 targeted (‘tailored’ or ‘genome-informed’) oncology drugs have been approved by the FDA for clinical use since the 1990s, and propelled into practice with growing payor coverage of tumor genomic profiling. This wave of targeted therapy approvals began with profoundly impactful medicines like trastuzumab in 1998 for...

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