Andreessen Horowitz December 9, 2025
Cures are already here — they just aren’t evenly distributed.
Some of the most innovative, life-saving therapies are also the most expensive. For example, Lenmeldy, a potentially curative therapy for Metachromatic leukodystrophy (MLD), carries a list price of $4.25 million per dose, making it the most expensive therapy in the world. Lenmeldy is not an outlier: many cell & gene therapies carry million-dollar price tags for a single dose.
The problem is that, given the current healthcare payment and care infrastructure, the distribution and administration of these treatments is both incredibly inefficient, and a terrible experience for patients and providers, alike:
- Insurance limitations: These therapies generate benefits that accrue over a lifetime, but today the price must be...
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