Medical Xpress January 11, 2026
In its effort to correlate genomic structure with gene function, the 4D Nucleome Consortium (4DN), led by Job Dekker, Ph.D., at UMass Chan Medical School, has extensively mapped and analyzed the three-dimensional folding of the human genome in human embryonic stem cells and immortalized fibroblasts over time. The result is the most detailed view of the four-dimensional human genome available and the identification of more than 140,000 looping interactions between genes and long-range regulatory elements. The study is published in Nature.
Integrating data from more than a dozen benchmarked genomic and computational techniques, the 4DN has created a critical framework for future studies that will further scientific inquiry into the architecture of the genome and how structural variations are associated...
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