Integrating Personalized Medicine With Population Health Management—The Path Forward

JAMA Network July 30, 2020
David C. Grossman, MD, MPH; Eric B. Larson, MD, MPH; Harold C. Sox, MD

In the near future, genome-wide DNA sequencing will likely become a part of regular medical practice and represents an era of “personalized medicine,” defined by the National Cancer Institute as a “form of medicine that uses information about a person’s own genes or proteins to prevent, diagnose, or treat disease.”¹ Genome-wide sequencing (GWS) can be a pathway not only to personalized medicine, but also to population health, which can be defined from a health care delivery perspective as the outcome when a health organization assumes responsibility for the health status of a defined population. Current examples of organizations that assume the responsibility of defined populations include the Veterans Health Administration, Kaiser Permanente, and numerous accountable care organizations. However, while personalized...

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