Medical Xpress August 29, 2024
F. nucleatum, an oral anaerobe, is frequently associated with colorectal cancer and is linked to increased cancer cell proliferation, metastasis, and poor treatment outcomes.
Recent studies have shown that F. nucleatum can trigger autophagy in cancer cells, leading to increased resistance to various chemotherapy drugs. Additionally, F. nucleatum promotes an immunosuppressive tumor microenvironment, hindering the infiltration of tumor-killing natural killer cells and T cells.
Therefore, eliminating F. nucleatum within tumors could be a strategic approach to enhance therapeutic outcomes for colorectal cancer. Antibiotics are widely used to combat bacterial infections.
However, they often indiscriminately kill both beneficial and harmful bacteria, potentially disrupting the intestinal microbiome. Bacterial vaccines offer a promising solution by targeting specific pathogens without harming the broader microbiome.
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