Bio-IT World January 19, 2022
Eight years ago, an international team of researchers proposed that the term “proteoform” be adopted to describe the vast number of forms of protein products from our genes—including changes due to genetic variations, alternative RNA splicing, and post-translational modifications—to reduce the semantic-related ambiguity in the study of proteins. Since these proteoforms can be turned on or off, understanding them with absolute molecular precision is required to demystify the world of how proteins function and “unlock the future of human biology,” says Neil Kelleher, professor of molecular biosciences, chemistry, and medicine at Northwestern University and faculty director of Northwestern Proteomics, as well as a world-renowned proteomics pioneer.
To that end, the nonprofit Consortium for Top-Down Proteomics recently proposed the Human Proteoform...
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