Eric Topol December 21, 2025
Particular Relevance to Sleep, Alzheimer’s Disease and Immune Surveillance
Jonathan Kipnis is a neuroscientist, the Alan A. and Edith L. Wolff Distinguished of Pathology and Immunology at Washington University, St. Louis, who discovered meningeal lymphatics and has been a prolific researcher in brain drainage and the continuous immune system surveillance of the brain.
I made this infographic with the help of Notebook LM to summarize many of the concepts we discussed. (Notebook LM is free and worth trying)
We went over his new review with 24 co-author leading experts in the recent issue of Neuron
A Clever Cover
The drainage system anatomy on influx and efflux (blue arrows)
The 3 ways the flow of glymphatics are modulated. I mentioned the...
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