Medical Xpress December 8, 2025
An international team led by the University of Michigan has introduced new methods that reveal which regions of the brain were active throughout the day with single-cell resolution.
Using mouse models, the researchers developed an experimental protocol and a computational analysis to follow which neurons and networks within the brain were active at different times. Published in the journal PLOS Biology, the study provides new insights into brain signaling during sleep and wakefulness, which hints at the bigger questions and goals that motivated the work.
“We undertook this difficult study to understand fatigue,” said senior author Daniel Forger, U-M professor of mathematics. “We’re seeing profound changes in the brain over the course of the day as we stay awake and...
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