VentureBeat March 18, 2025
Carl Franzen

Graphics processing units (GPUs), the expensive computer chips made by the likes of Nvidia, AMD and Sima.ai, are no longer the only way to train and deploy artificial intelligence.

Biological Black Box (BBB), a Baltimore-founded startup developing a new class of AI hardware, has emerged from stealth with its Bionode platform—a computing system that integrates living, lab-grown neurons with traditional processors.

The company, which has been operating quietly while filing patents and refining its technology, believes its biological computing approach — growing new neurons specifically to act as computer chips using donor human stem cells and rat-derived cells — could offer a low-power, adaptive alternative to conventional GPUs.

“Over the last 20 years, three independent fields—biology, hardware, and computational tools—have...

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