Becker's Healthcare November 22, 2024
GLP-1s and GLP-2s, or glucagon-like peptides, are both secreted from gut endocrine cells and promote nutrient absorption. As medications, they differ vastly.
There is only one FDA-approved GLP-2 medication: Takeda Pharmaceuticals’ Gattex (teduglutide). The federal agency first approved the injectable in 2012, and it is for patients ages 1 and older who have short bowel syndrome and are dependent on parenteral support.
Gattex works to enhance gastrointestinal fluid — also called wet weight — absorption to wean patients off parenteral nutrition or intravenous fluid support.
Since the GLP-2 medication increases absorption through the intestine, a potential side effect is fluid retention, which might lead to weight gain....
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