Becker's Healthcare March 10, 2025
Francesca Mathewes

The use of GLP-1s in the perioperative period surrounding major surgeries, such as total joint arthroplasties, is a growing source of concern among orthopedic surgeons.

A study presented at the 2025 Annual Meeting of the American Academy of Orthopaedic Surgeons examined the relationship between the patient’s last dose of Ozempic, a common GLP-1, and anesthesia-related complications during total knee and hip arthroplasties.

Here are 10 takeaways from the study:

1. The study, “Optimal Timing for Cessation of GLP-1 Agonist Before Elective Total Hip and Knee Arthroplasty,” obtained data from the TriNetX Research Network, a multi-institutional national aggregated database, to identify patients who underwent TKA or THA from Jan. 1, 2018, to Jan. 1, 2023.

2. Patients who used...

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