Inside Precision Medicine February 24, 2025
Unraveling the genetic underpinnings of depression could pave the way for more effective treatments, and a groundbreaking study has now identified 287 genetic risk loci linked to the disorder—49 of them newly discovered. In one of the most extensive cross-ancestry genetic studies on depression, analyzing genetic data from over 1.7 million individuals across diverse ancestries, researchers pinpointed key variants that may influence depression by altering gene regulation and transcription factor binding. This large-scale genetic study, published in Nature Human Behaviour, not only deepens our understanding of depression’s molecular mechanisms but also highlights promising targets for future drug development.
A comprehensive cross-ancestry meta-analysis
Prior genome-wide association studies (GWAS) have identified genetic risk factors for depression; however, a significant portion of the...
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