Gene regulation study finds coordination between basic cellular processes is lost with increasing age

Medical Xpress September 3, 2024
Gabriele Meseg-Rutzen, University of Cologne

Gene regulation in our cells—the decision on which proteins are produced for the various processes of the cell—is strictly regulated. It has long been assumed that this regulation deteriorates with age. But until now, it has been unclear how exactly the regulation of individual processes, and above all, the coordination between the processes changes.

Professor Dr. Andreas Beyer and his team from the University of Cologne’s CECAD Cluster of Excellence for Aging Research have now used a mathematical model to show that the regulation of genes involved in the same process in the cell changes relatively little over the course of a person’s life. However, the coordination between different cellular processes becomes less and less effective. The study is published...

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