Gender-affirming medications tied to lower depression risks

Transgender, nonbinary and gender-diverse adults who take gender-affirming hormone therapy are at less risk of depression than those who do not, according to a study published March 17 in JAMA Network Open.

Compared to cisgender adults, this population has a two- to fourfold increased risk of depression. Past research has shown gender-affirming therapies to improve mental health outcomes, but data are lacking in primary care settings, according to researchers of the study.

The observational study followed 3,592 patients who received...

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