Inside Precision Medicine February 7, 2024
Although not necessarily the father of exposomics, Christopher Wild certainly gave life to the term exposome in the title of his August 2005 paper published in Cancer Epidemiology, Biomarkers & Prevention. Fresh on the heels of the completion of the Human Genome Project, Wild contended that while the identification of genetic variants or single nucleotide polymorphisms (SNPs) was significant in disease susceptibility and development, most of these variants would only influence human health if perturbed by environmental exposure.
In advocating for broader study of the exposome, which he defined as life-course environmental exposures from the prenatal period and onward, Wild wrote: “Environmental exposures are acknowledged to play an overwhelmingly important role in those common chronic diseases … which constitute the...