KevinMD July 27, 2025
Robert Den, MD

Clinical trials are the cornerstone of progress in cancer treatment. Yet, paradoxically, the very patients these trials are designed to help often face the greatest obstacles to participation. While the concept of “patient-centered” clinical trials has been around for years, more than 20 percent of U.S. clinical trials fail to accrue a sufficient number of participants, forcing them to fold.

Why aren’t patients enrolling in clinical trials?

While there have been significant strides in oncology research and treatment, there is still room to grow. Currently, only about 7.1 percent of adult cancer patients participate in treatment trials, and just 21.9 percent participate in any form of cancer research. While multiple factors can limit participation, and not every barrier can be...

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