Medscape July 30, 2024
Fecal microbiota transplantation (FMT) for Parkinson’s disease (PD) is safe but does not offer clinically meaningful improvement in symptoms, results of a new, randomized placebo-controlled trial show.
However, investigators discovered some interesting insights from the study, which they believe may help in designing future “improved, and hopefully successful, trials” with the intervention.
“Further studies — for example, through modified fecal microbiota transplantation approaches or bowel cleansing — are warranted,” they concluded.
The study was published online in JAMA Neurology on July 29.
Gut Dysfunction an Early Symptom
Investigators led by Filip Scheperjans, MD, Helsinki University Hospital, Finland, explained that gut dysfunction is a prevalent, early symptom in PD and is associated with more rapid disease progression.
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