Health Affairs October 3, 2023
Mental illnesses are associated with significant morbidity and mortality. Although more Americans are engaging in mental health care, many people living with a mental illness do not receive treatment. Those in treatment often do not find complete relief: More than 13 percent of US adults use antidepressants, but double-blind, placebo-controlled trials indicate that they improve symptoms in an extra 20 out of 100 people (in addition to the 20 to 40 that respond to a placebo) and can carry unpleasant side effects. Psychotherapy, while helpful for some, is difficult to access.
Enter psychedelics, including 3,4-Methylenedioxymethamphetamine (MDMA) and psilocybin, which have been demonstrated as a viable alternative for treating conditions across the mental health spectrum. Phase 3 clinical trials have found...
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