Healthcare IT Today September 24, 2025
The following is a guest article by Ashley Daigneau, Head of Clinical Trials at Verana Health
Active-controlled trials (ACT) are becoming a backbone of modern medicine. By comparing a new therapy directly against the existing standard of care, rather than a placebo, these trials generate direct head-to-head evidence on relative efficacy and safety. It’s an approach that helps clinicians, regulators, and payers confidently determine whether a novel treatment truly advances patient outcomes or is at least non-inferior compared to current practice.
With market competition and pressure to prove substantial improvement over existing treatments, active-controlled trials are increasingly common.
A fundamental challenge arises, however, when the comparator drug—the “standard of care”—has an incomplete safety and effectiveness profile, especially in diverse patient...
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