Advisory Board March 3, 2025

Multiple studies have found that men and women experience pain differently, with women frequently reporting they feel pain more intensely, more often, and for a longer time, Annika Neklason reports for The Hill.

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The role of biological sex in pain

According to researchers, each sex has distinct cells that appear to be involved in processing pain.

“The biological processing of pain, regardless of how much pain is produced, is dramatically sex dependent,” said Jeffrey Mogil, a psychology professor at McGill University. “Different genes are being used in both sexes — different proteins, different cell types, dramatically different biology in each case.”

According to a fact sheet that Mogil and other...

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