NEJM September 19, 2024
Since the pioneering discovery of secretin-like activity by Bayliss and Starling in 1902, scientists have pursued the mysteries of gut-hormone biology, such that the peptide hormone–secreting enteroendocrine-cell system is now understood to be the largest endocrine system, contributing dozens of peptide hormones that regulate hunger, satiety, gut motility, and barrier and immune function, as well...