Medical Xpress October 11, 2025
European College of Neuropsychopharmacology

It is known that depression is linked to an increased incidence of metabolic diseases. Now scientists have discovered that different types of depression are linked to different cardiometabolic diseases. This work was presented at the ECNP Congress in Amsterdam.

Over seven years, researchers tracked 5,794 adults enrolled in the Netherlands Epidemiology of Obesity (NEO) Study, all of whom were free of diabetes and at the study’s start. At the start of the study, each participant completed a comprehensive questionnaire to assess depressive symptoms. The team identified two distinct depressive profiles: one typified by “melancholic” symptoms (such as early morning awakening and reduced appetite), and another by “atypical/energy-related” symptoms (such as fatigue, increased sleep, and increased appetite).

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