Medical Xpress August 22, 2024
A computational model built by researchers at the Institute of Research in Biomedicine (IRB Barcelona) and the Centre for Genomic Regulation (CRG) can predict which drugs will be most effective in treating diseases caused by mutations that can bring protein synthesis to a halt, resulting in unfinished proteins.
The findings, published today in Nature Genetics, mark an important step in helping personalize treatment by matching patients with specific mutations with the most promising drug candidate. The predictive model, a publicly available resource called RTDetective, can accelerate the design, development, and efficacy of clinical trials for many different types of genetic disorders and cancers.
Truncated proteins are the result of protein synthesis coming to a sudden halt. In our bodies, this...
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