Inside Precision Medicine February 22, 2024
Mapping dysfunctional circuits in the brain by electrically stimulating areas deep within it could improve the treatment of four neurological disorders, research suggests.
The findings, in Nature Neuroscience, may help identify new targets and strategies for dystonia, Parkinson’s disease, Tourette Syndrome, and obsessive-compulsive disorder (OCD).
The researchers identified those circuits in the frontal cortex with the best responses to treatment with deep brain stimulation (DBS), helping them to understand areas of dysfunction in each disorder.
“Clinically, the identified circuits directly represent therapeutic targets that could inform stereotactic targeting in neurosurgery and potentially non-invasive neuromodulation at the cortical level,” reported Ningfei Li, PhD, from Charité–University Medicine Berlin in Germany, and colleagues.
DBS involves surgical implantation of electrodes in the brain to...
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