Eric Topol September 17, 2025
Recent groundbreaking reports highlight our newfound potential to prevent diseases
Primary Prevention means a disease or condition is averted. The term was coined and introduced by Leavell and Clark in the late 1940s. Now, about 75 years later, we’ve yet to achieve any substantive primary prevention with the notable exception of vaccinations that prevent infectious diseases. Of the 3 major age-related diseases that I focused on in SUPER AGERS—cardiovascular, cancer, and neurodegenerative—we have not prevented the latter two. Remember screening for cancer (such as mammography, colonoscopy, PSA, or total body MRI as some have advocated without adequate data) is a secondary prevention, with the objective of finding cancer at an early stage. Nothing meaningful has yet been shown to prevent...
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