KevinMD May 25, 2024
Nancie Wiseman Attwater

For many people with autoimmune disease, fatigue is the most debilitating symptom. Why autoimmune disease and fatigue go together is not entirely understood, although inflammation may be part of the reason. Other possible factors include pain, poor sleep, inactivity, and depressed mood. Fatigue is not just feeling tired. Fatigue is composed of both physical fatigue and mental fatigue. Unlike being tired, fatigue is rarely resolved with rest or sleep. Trying to get through the fatigue is difficult or impossible. It is difficult to ignore. One minute you feel fine; the next, you are so tired you can’t help but lay down. It makes you wonder if you are just lazy, getting old, or coming down with a flu or bug.

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