Advisory Board May 8, 2024
Currently, the vast majority of Alzheimer’s cases don’t have a clearly identified cause, but a new study published in Nature Medicine suggests that having two variants of the APOE4 gene could be the cause behind specific cases of the disease.
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Study details
For the study, researchers analyzed pathological data from 3,297 brain donors and biomarkers and clinical data from 10,039 people, including over 500 people with two copies of APOE4, a gene variant that has long been known to increase a person’s risk of developing Alzheimer’s.
The researchers found that nearly every patient with two copies of APOE4 developed the biological pathology of Alzheimer’s. By age 55, more than 95% of...
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