MedPage Today July 28, 2025
Two interventions demonstrate benefit in older adults at risk of cognitive decline
TORONTO — Two lifestyle interventions — one structured, the other self-guided — improved cognition in older adults at risk of cognitive decline, the 2-year U.S. POINTER trial showed.
Global cognitive scores increased from baseline in both the structured group (mean annual increase rate 0.243 SD, 95% CI 0.227-0.258) and the self-guided group (0.213 SD, 95% CI 0.198-0.229), reported Laura Baker, PhD, of Wake Forest University School of Medicine in Winston-Salem, North Carolina, at the Alzheimer’s Association International Conference.
The mean annual increase was greater by 0.029 SD (95% CI 0.008-0.050, P=0.008) in the structured compared with the self-guided group. The findings were published simultaneously in JAMA.
Both interventions...
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