STAT May 8, 2024
Tolerance is the holy grail in calming autoimmune disease, a truce in the immune system’s faulty battle against the body’s own fabric. In type 1 diabetes, immune fighters attack beta cells in the pancreas that produce insulin, the hormone that controls glucose levels in the blood.
Scientists have tried to enlist defenders in the form of regulatory T-cells, or Tregs, extra white blood cells whose job is to tamp down the misguided immune response. A paper published Wednesday in Science Translational Medicine describes a Phase 2 clinical trial that infused an expanded version of patients’ own Tregs into 110 children and adolescents newly diagnosed with type 1 diabetes. It was intended to preserve their remaining insulin-making cells.
It didn’t work....
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