Forbes January 12, 2026
High patient out-of-pocket costs and side effects are causing a large percentage of people who start on weight loss medications to stop. Discontinuing obesity medicines means the weight comes back and people lose the cardiovascular and metabolic benefits conferred by the drugs.
Concerns about weight rebound after discontinuing GLP-1s have long been noted. But STAT News posted a rather sobering account last week of just how negatively impactful stopping medications can be. It cited a recently published British Medical Journal review of 37 studies, tallying an aggregate of more than 9,300 participants, in which approximately 50% of the people who started on the drugs stop taking them within 1 year. The return to baseline weight occurred in an average of...
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