CAR T-cell therapies can be effective – but safety concerns mount

Advisory Board March 19, 2024
Chloe Bakst, Rachael Peroutky

CAR T-cell therapies, cancer treatments that involve genetically modifying immune cells, have shown promise against several types of cancer, most recently brain cancer. However, there are a growing number of safety concerns that could limit its use in the future.

CAR T-Cell Therapy Demand Estimator

CAR T-cell therapy could be effective for brain cancer

In CAR T-cell therapy, white blood cells called T cells are removed from a patient’s blood before being genetically modified to make proteins called chimeric antigen receptors (CAR). These receptors allow T cells to target and destroy cancer cells. The genetically modified T cells are then infused back into a patient’s blood.

So far, FDA has only approved CAR T-cell therapies to treat blood cancers,...

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