Health Imaging January 17, 2025
New imaging data suggest that subtle changes in the brain can be seen up to two decades prior to symptom onset in patients with Huntington’s disease.
Published in Nature Medicine, the analysis highlights the utility of combining MRI findings with blood and spinal fluid biomarkers to detect the earliest signs of neurodegeneration related to the debilitating condition. Experts hope their findings offer valuable insights that could lead to improved interventions for preserving brain function.
The genetic disease is caused by alterations of three DNA blocks (C, A and G) in the Huntington gene, which expand throughout a person’s life. Known as somatic CAG expansion, this process speeds up neurodegeneration, which experts now believe can be visualized in certain...
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