Andreessen Horowitz December 10, 2025
a16z New Media

The biggest problems builders will tackle in 2026, according to our American Dynamism and Apps partners

Yesterday, we shared the first installment of our Big Ideas package, which included the problems that our Infrastructure, Growth, Bio + Health, and Speedrun partners think startups will tackle in 2026.

We’re back with part 2 of this package today, featuring contributions from our American Dynamism and Apps teams. Stay tuned for ideas from our Crypto team tomorrow.

American Dynamism

Building the AI-native industrial base

David Ulevitch

America is rebuilding the parts of the economy that create real strength. Energy, manufacturing, logistics, and infrastructure are back in focus, and the most important shift is the rise of an industrial...

Today's Sponsors

Venturous
ZeOmega

Today's Sponsor

Venturous

 
Topics: Investments, Trends
Anthropic closes latest funding round above $10 billion and could go higher, sources say
Biotech investor Cormorant secures $150M for another SPAC deal
AI Startups Hit Unicorn Status at Seed Stage
VieCure Raises $43 Million to Help Democratize Access | Avalon Healthcare Solutions Announces Strategic Investment
Synthesia raises $200M, with $4B valuation

Share Article