Inside Precision Medicine January 3, 2025
Gene transfer for kidney disease is challenging. To address this, a team used “context-dependent selection of AAV capsids.” They found that local delivery of AAV-KP1, but not AAV9, via the renal vein or pelvis effectively transduces proximal tubules with minimal off-target liver transduction. Meanwhile, systemic AAV9, but not AAV-KP1, enhances proximal tubule and podocyte transduction in chronic kidney disease.
These differences are partly due to the AAVs’ varying pharmacokinetics, the researchers found. The team was from Oregon Health & Science University School of Medicine.
They conducted a barcode-seq-based comparison of 47 AAV capsids administered through different routes in mice, followed by individual validation. Besides the key delivery differences for AVVs, they found that renal pelvis injection overcomes pre-existing immunity,...
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