Advisory Board June 10, 2024

According to a new review published in The Lancet Psychiatry, around 15% of people reported having withdrawal symptoms after they stopped taking antidepressants — significantly fewer than previously reported.

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Review details and key findings

For the review, researchers analyzed data from 79 studies with 21,002 patients. Of the studies, 44 were randomized controlled trials, and 35 were observational studies.

Among the patients, 16,532 discontinued antidepressant use, while 4,470 patients discontinued use of a placebo. The mean age of patients was 45 years old, and 72% were female.

Overall, the researchers found that roughly 15%, or one in six to seven patients, experienced antidepressant discontinuation symptoms after they stopped taking antidepressants....

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