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Are we overlooking something critical in cell and gene therapy research?
BioPharma Dive December 16, 2024
Sponsored content By PHC Corporation of North America
Cell & gene therapy stands at the forefront of modern medicine, promising transformative treatments for previously intractable diseases. But, as the field continues to advance, a growing body of evidence suggests that we may need to fundamentally rethink one of the most basic aspects of cell culture: O2 concentration.
While the field has made remarkable strides in optimizing numerous culture parameters, the continued use of non-physiological O2 levels could be stifling our efforts to conduct more insightful research and develop better, more effective therapies.
Normoxia — the norm for cells?
Conventionally, mammalian cells have been cultured at atmospheric or ‘normoxic’ O2 levels — that is, at O2 levels ranging from 20–21%....
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