MedPage Today August 27, 2024
— Results differ from previous studies suggesting an increased risk
First-line antidepressants were associated with a decreased risk of falls and related injuries among older adults, according to a cohort study.
Of more than 100,000 Medicare beneficiaries newly diagnosed with depression, use of first-line antidepressants was associated with a decreased risk of falls and related injuries compared with no treatment, with adjusted hazard ratios ranging from 0.74 (95% CI 0.59-0.89) for bupropion (Wellbutrin) to 0.83 (95% CI 0.67-0.98) for escitalopram (Lexapro), reported Wei-Hsuan Lo-Ciganic, PhD, MSPharm, of the University of Pittsburgh, and co-authors.
The event rates for falls and related injuries were also lower for patients treated with bupropion compared with those who did not receive treatment (63 vs 87...
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