MedPage Today July 28, 2024
— Testing recommended only for patients with cognitive impairment, not the “worried well”
PHILADELPHIA — A blood test performed better than a standard evaluation by primary care doctors or dementia specialists in detecting Alzheimer’s disease among people with cognitive symptoms.
The PrecivityAD2 blood test algorithm — which produced an outcome called the amyloid probability score 2 (APS2) — had a diagnostic accuracy of 91%, compared with 61% diagnostic accuracy after standard clinical evaluations by primary care physicians, and 73% accuracy after evaluations by dementia specialists.
The APS2 incorporates the ratio of plasma phosphorylated tau 217 (p-tau217) relative to non-p-tau217, combined with an amyloid-beta 42/amyloid-beta 40 plasma ratio, based on mass spectrometry assays. Its accuracy was compared with physician diagnoses based...
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