MedPage Today October 25, 2024
— Easy to apply, uses parameters commonly measured in outpatient and inpatient settings
A risk stratification algorithm may be able to predict which patients with advanced chronic liver disease are at risk of developing hepatocellular carcinoma (HCC), according to a large-scale multicenter study.
Among more than 2,300 patients with advanced chronic liver disease, a six-parameter algorithm, known as PLEASE, indicated that patients stratified as high risk had a cumulative risk of developing de novo HCC within 2 years of 15.6% versus 1.7% among those in the low-risk category, reported Jonel Trebicka, MD, PhD, of Münster University in Germany, and colleagues.
Comprising the six parameters were platelet count less than 150 × 109/L, liver stiffness measurement (LSM) greater than or equal...
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