News-Medical.Net August 29, 2024
Researchers at the Center for Algorithmic and Robotized Synthesis within the Institute for Basic Science have taken a significant step forward in understanding the stability of proteins by leveraging the power of AI. The research team used AlphaFold2 to explore how mutations affect protein stability-;a crucial factor in ensuring proteins function correctly and do not cause diseases like Alzheimer’s.
DeepMind’s AlphaFold algorithm, which can accurately predict a protein’s structure from its gene, has been a game-changer across the field of biology, making structural biology accessible to everyone. Despite this immense success, two fundamental questions remain unanswered: Will the predicted structures fold correctly and stay folded? And a general question about AI algorithms: how does AlphaFold actually work?
A critical limitation...
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