AI Model Detects Early Pancreatic Cancer on CT Scans

Medscape July 4, 2025
Edited by Gargi Mukherjee

TOPLINE:

An artificial intelligence (AI) model achieved a sensitivity of 91.8% in detecting pancreatic cancer on CT scans at diagnosis, with a 53.9% sensitivity for scans taken 1 year or more before diagnosis. The model demonstrated a sensitivity of 82.9% for stage I pancreatic cancer detection, suggesting potential for earlier diagnosis.

METHODOLOGY:

• This analysis included 1083 patients (mean age, 68.9 years; 575 men) with biopsy-confirmed pancreatic cancer from Danish medical registries between 2006 and 2016.
• Researchers evaluated 1220 CT scans, including 1022 concurrent diagnosis scans acquired within 2 months of histopathologic diagnosis and 198 prediagnosis scans obtained before diagnosis (median, 7 months prior).
• The PANCANAI model, previously trained on 2134 portal venous CT scans, was tested for pancreatic cancer...

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